The prevalence of barretts esophagus is 10 to 15 in patients who are undergoing endosocopy for gastroesophageal reflux disease and 1 to 2 in asymptomatic american adults barretts esophagus represents metaplastic columnar tissue with specialized intestinal metaplasia and this condition carries an increased risk of esophageal adenocarcinoma. Esophageal adenocarcinoma eac is a major cause of cancer related morbidity and mortality in western countries the incidences of eac and its precursor barretts esophagus be have increased substantially in the last four decades current care guidelines recommend that endoscopy be used for the ea . Barretts esophagus be a metaplastic columnar epithelium of the distal esophagus is the known precursor lesion for ea ea and be occur more frequently in white men over 50 years old as well as in people with frequent symptoms of gastroesophageal reflux in smokers and in people who are obese. Familial barretts esophagus and esophageal adenocarcinoma is increasingly becoming more recognized current guidelines also now incorporate family history as a risk factor for barretts esophagus recent studies include dna sequencing of multigenerational families in addition to previously performed gwas studies
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